70 year old male. Over the past month, the patient developed a cough with hemorrhagic sputum, shortness of breath, left-sided pain in the chest. CT scan revealed atelectasis of the left upper lobe. Bronchoscopy showed complete tumor occlusion of the left main bronchus. Histopathological diagnosis of biopsy – squamous cell carcinoma. The patient has been assessed as inoperable. In agreement with the oncologist, it was decided to perform a laser resection before chemotherapy, to avoid side effects during the procedure. laser resection was done using VELASTM 30W Surgical Diode Laser System. Except the laser resection, silicon stent has been placed in the left main bronchus to avoid re-closing. After procedure the patient feels good. Eendoscopically left main bronchus is fully pass through. Histomorphology of the resected tumor proved the diagnosis of squamous cell carcinoma.